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 A Deep Dive into the Clinical Studies of Lactoryzol

In the rapidly advancing field of skincare, the validation of product efficacy through rigorous clinical studies is crucial. These studies provide the scientific foundation necessary to substantiate the claims made by skincare products, ensuring they deliver tangible benefits to consumers. Lactoryzol, a novel rice-based postbiotic active from BioAktive, has emerged as a promising ingredient for treating sensitive and distressed skin. This article offers an in-depth exploration of the clinical studies conducted on Lactoryzol, emphasizing the methodologies, detailed results, and the broader implications for skincare routines and product development.

Study Methodologies

The clinical evaluation of Lactoryzol involved a series of meticulously designed in vivo tests, each targeting specific skin health parameters. The studies were conducted with 30-40 volunteers, aged between 22 and 54 years, and divided into placebo and experimental groups. This section provides a comprehensive overview of the methodologies employed in these studies.

Moisturization Tests

The objective of the moisturization tests was to assess Lactoryzol's efficacy in enhancing skin hydration. Two formulations, containing 10% and 20% Lactoryzol, were tested. Volunteers applied these emulsions twice daily over an eight-week period. Skin hydration levels were measured at baseline and subsequently every two weeks using corneometry, a reliable method for assessing skin moisture content. The study aimed to determine the degree of improvement in skin hydration provided by Lactoryzol compared to a placebo.

Skin Sensitivity Tests

To evaluate the impact of Lactoryzol on skin sensitivity, a study was designed involving the application of a 5% Lactoryzol cream twice daily. Sensitivity was assessed using a lactic acid stinging test, a common method for evaluating skin reactivity. After cleansing and resting, a 50 μL of 10% lactic acid solution on 0.5cm diameter filter paper was applied to the nasolabial fold of the volunteers. Participants rated their stinging sensation and skin reaction on a four-point scale (0: no sting, 1: light sting, 2: mild sting, 3: moderate sting, 4: severe sting). Skin redness was also measured using a chromameter to quantify erythema. These assessments were performed at baseline and at the end of the eight-week period.

Wrinkles, Elasticity, and Firmness Tests

This study aimed to measure Lactoryzol's effects on skin wrinkles, elasticity, and firmness. Volunteers applied a 5% Lactoryzol cream twice daily for eight weeks. Skin elasticity was assessed using a cutometer, which measures the skin's ability to return to its original state after being deformed. Wrinkle reduction was evaluated through high-resolution imaging and analysis, quantifying changes in wrinkle depth and number. These measurements were taken at baseline and at the end of the study period to determine the efficacy of Lactoryzol in improving skin smoothness and firmness.

Skin Penetration Tests

The skin penetration tests were designed to investigate Lactoryzol's potential to enhance the transdermal absorption of active ingredients. An in vitro three-dimensional skin model was used for this purpose. The study tested the penetration of ascorbyl glucoside (AA2G) using formulations containing 5% and 10% Lactoryzol. A 2.0% ascorbyl glucoside physiological saline solution served as a blank control. High-performance liquid chromatography (HPLC) was employed to quantify the content of ascorbic acid in the skin layers, providing a measure of Lactoryzol's efficacy as a penetration enhancer.


Detailed Results


The moisturization tests yielded significant results, demonstrating Lactoryzol's ability to enhance skin hydration. The 10% and 20% Lactoryzol emulsions increased skin hydration by 20%-35% and 25%-56%, respectively, compared to the placebo. The corneometry readings showed a progressive increase in skin moisture content over the eight-week period. These findings indicate that Lactoryzol effectively boosts the skin's moisture levels, making it an ideal ingredient for products targeting dry and sensitive skin.

Reduced Skin Irritation

The skin sensitivity tests revealed a notable reduction in skin irritation among participants using Lactoryzol. The lactic acid stinging test results showed a decrease in stinging sensation scores by 20%-45%. Additionally, measurements of skin redness indicated a significant reduction in erythema, with participants exhibiting less redness and irritation after applying the Lactoryzol cream. These outcomes suggest that Lactoryzol can soothe irritated skin and alleviate redness, making it suitable for individuals with sensitive skin conditions.

Wrinkles, Elasticity, and Firmness

The study on wrinkles, elasticity, and firmness demonstrated Lactoryzol's anti-aging potential. The high-resolution imaging analysis revealed a reduction in the number of wrinkles by 8%-30%. The cutometer readings indicated significant improvements in skin elasticity, with participants' skin showing enhanced resilience and firmness. The overall improvement in skin smoothness and firmness underscores Lactoryzol's effectiveness in reducing the visible signs of aging.

Skin Penetration

The skin penetration tests provided compelling evidence of Lactoryzol's ability to enhance the transdermal absorption of active ingredients. The HPLC analysis showed that formulations containing 5% and 10% Lactoryzol significantly increased the penetration of ascorbyl glucoside into the skin layers. The dose-dependent effect observed suggests that higher concentrations of Lactoryzol could further improve the delivery of active ingredients in skincare formulations. This property makes Lactoryzol a valuable addition to products designed to deliver potent actives deep into the skin.

Implications for Skincare

The comprehensive results from these clinical studies have profound implications for skincare routines and product development. Lactoryzol's multifunctional benefits position it as a versatile ingredient in skincare formulations. Here are some key takeaways:

  1. Enhanced Moisturization: Lactoryzol's ability to significantly boost skin hydration makes it an excellent choice for moisturizers and hydrating serums, particularly for individuals with dry or sensitive skin.

  2. Reduction of Skin Sensitivity: The reduction in skin irritation and redness observed in the studies suggests that Lactoryzol can be effectively used in products designed for sensitive skin, such as calming creams and anti-redness treatments.

  3. Anti-Aging Benefits: The improvements in skin elasticity and wrinkle reduction highlight Lactoryzol's potential in anti-aging products, offering a natural and effective solution for reducing the visible signs of aging.

  4. Enhanced Delivery of Active Ingredients: Lactoryzol's ability to enhance the transdermal absorption of active ingredients makes it a valuable addition to formulations containing potent actives, improving their efficacy and overall performance.


The clinical studies on Lactoryzol provide robust evidence of its efficacy and potential as a key ingredient in skincare products. By enhancing skin hydration, reducing irritation, improving skin elasticity, and supporting the delivery of active ingredients, Lactoryzol offers a comprehensive solution for improving skin health. These findings underscore the importance of rigorous clinical testing in the development of innovative skincare solutions, ensuring that products not only meet but exceed consumer expectations. As the skincare industry continues to evolve, ingredients like Lactoryzol, backed by solid scientific research, will play a crucial role in shaping the future of skincare.

For cosmetic chemists and formulators looking to harness the latest advancements in skincare science, Lactoryzol offers a compelling option. More details about this innovative ingredient can be found by visiting the Lactoryzol Product Page.

About Us:

BioAktive Specialty Products offers a range of plant based and nature inspired ingredients for skincare and cosmetics. We are part of BioAktive Group Inc, a US company supplying best in class ingredients, raw materials and solutions at the intersection of chemicals and life sciences. For more information, please email us or

For more information, please contact:

Solomon Matzner


BioAktive Group Inc

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